Interactive structural visualizations of complete mapping of mutations to the RBD that reduce binding by polyclonal sera from mice vaccinated with a mosaic-8 or homotypic Beta variant RBD vaccine

Below are links to interactive visualizations of the effects of single mutations to the Beta (B.1.351) SARS-CoV-2 spike receptor-binding domain (RBD) on binding by plasmas from mosaic-8b RBD-mi3-vaccinated mice, SARS2 Beta homotypic RBD-mi3-vaccinated mice, or mosaic-8b RBD-mi3-vaccinated NHPs.

These visualizations are built using dms-view. These experiments are described in add link, and raw data are available here. This vaccine was first described in Cohen, et al (2021).

Sites where mutations reduce binding are shown for each serum, and are mapped to the ACE2-bound Beta RBD, made by aligning PDB 6M0J and PDB 7LYQ or to the RBD of the Beta variant.

Interactive visualizations of the escape maps for mice:

• Plasma escape mapped to the ACE2-bound Beta RBD (made by aligning 6M0J and 7LYQ)

Interactive visualizations of the escape maps for NHPs:

• Plasma escape mapped to the ACE2-bound Beta RBD (made by aligning 6M0J and 7LYQ)