Near real-time data on the human neutralizing antibody landscape to influenza virus to inform vaccine-strain selection for the Northern Hemisphere in February 2026
Briefly, this study used sequencing-based neutralization assays to measure titers to influenza viruses with HAs from seasonal H3N2 and H1N1 viruses representative of those circulating in the fall-winter of 2025-2026 against a set of human sera collected in 2025.
The numerical data and computer code are at https://github.com/jbloomlab/flu-seqneut-2025to2026
Documentation of results rendered as of Sat Feb 14 17:25:06 2026
Titers for all sera
Interactive chart of titers
Per-serum neutralization titers
human
Per-plate counts and curve fits
human
Summary of data dropped during quality control
Notebook summarizing QC drops
Interactive charts summarizing human titers (vertical)
Interactive charts summarizing human titers (horizontal)
Fold-change charts
titer change after vaccination for PENN cohort (vertical)
titer change after vaccination for PENN cohort (horizontal)