Mapping mutations to the SARS-CoV-2 B.1.351 RBD that reduce binding of polyclonal plasmas from B.1.351-convalescent individuals
Below are links to interactive visualizations of the effects of single mutations to the B.1.351 SARS-CoV-2 spike receptor-binding domain (RBD) on binding by plasmas from B.1.351 convalescent individuals.
These visualizations are built using dms-view. These experiments are described in add link, and raw data are available here. Plasmas from individuals infected with the B.1.351 (Beta) variant were first described in Cele, et al. (2021).
The escape maps for plasmas from individuals infected with SARS-CoV-2 in early 2020 were first described in Greaney et al. (2021a). These convalescent plasma samples were first described in Crawford et al. (2020).
Sites where mutations reduce binding are shown for each serum, and are mapped to the ACE2-bound Wuhan-Hu-1 RBD structure (PDB 6M0J) or to the RBD of the B.1.351 variant (PDB 7LYQ).
Interactive visualizations of the escape maps: