Complete mapping of mutations to the SARS-CoV-2 spike receptor binding domain that escape antibody recognition

Mutational antigenic profiling of Crowe-lab antibodies to SARS-CoV-2 RBD

View the Project on GitHub jbloomlab/SARS-CoV-2-RBD_MAP_Crowe_antibodies

Interactive structural visualizations of escape mutation maps

Below are links to interactive visualizations of the effects of single mutations to the SARS-CoV-2 spike receptor-binding domain (RBD) on recognition by ten monoclonal antibodies. These visualizations are built using dms-view. These data are described in this paper.

Strong sites of escape are shown for each antibody, and are mapped to the ACE2-bound RBD structure (PDB 6M0J). In this structure, ACE2 is in dark gray and the RBD is light gray. The logo plots are colored by how mutations impact ACE2 binding or RBD expression (see the scale bars in Figure 5B of the pre-print).

dms-view renderings for strong sites of escape for each antibody: