Below are links to interactive visualizations of the effects of single mutations to the SARS-CoV-2 spike receptor-binding domain (RBD) on binding by polyclonal convalescent human sera. These visualizations are built using dms-view. These experiments are described in Greaney, et al. (2021), and raw data are available here.
Sites where mutations reduce binding by serum antibodies are shown for each serum, and are mapped to the ACE2-bound RBD structure (PDB 6M0J). At least two time points per individual were mapped, and each time point is shown separately.
dms-view renderings for all 23 sera mapped to the ACE2-bound RBD structure (static views shown in Figure S3):
dms-view renderings highlighting various observations on which mutations affect binding of serum antibodies to the RBD: