Complete map of SARS-CoV-2 RBD mutations that escape the monoclonal antibody LY-CoV555 and its cocktail with LY-CoV016

Mutational antigenic profiling of LY-CoV555 antibody alone and in cocktail with LY-CoV016 using yeast-displayed SARS-CoV-2 RBD

View the Project on GitHub jbloomlab/SARS-CoV-2-RBD_MAP_LY-CoV555

Interactive structural visualizations of escape mutation maps

Below are links to interactive visualizations of the effects of single mutations to the SARS-CoV-2 spike receptor-binding domain (RBD) on recognition by LY-CoV555 and the LY-CoV555+LY-CoV016 cocktail, alongside our prior escape maps for LY-CoV016 (Starr et al. 2021). These visualizations are built using dms-view. These experiments are described in this paper, and raw data is available here.

Sites of escape are shown for each antibody, and are mapped to the ACE2-bound RBD structure (PDB 6M0J or antibody-bound structures (LY-CoV555: PDB 7KMG, or LY-CoV016: PDB 7C01).

dms-view renderings for escape maps projected onto the ACE2-bound RBD structure (use the upper-left menu bar to select LY-CoV016 or LY-CoV555+LY-CoV016 data projections):

dms-view renderings for escape maps projected onto LY-CoV555- or LY-CoV16-bound RBD structures: