Antibodies to the SARS-CoV-2 receptor-binding domain that maximize breadth and resistance to viral escape

View the Project on GitHub jbloomlab/SARS-CoV-2-RBD_MAP_Vir_mAbs

Interactive structural visualizations of escape mutation maps

Below are links to interactive visualizations of the effects of single mutations to the SARS-CoV-2 spike receptor-binding domain (RBD) on recognition by each antibody. These visualizations are built using dms-view. These experiments are described in our preprints here and here, and raw data is available here.

Sites of escape are shown for each antibody, and are mapped to the ACE2-bound RBD structure (PDB 6M0J.

dms-view renderings for escape maps projected onto the ACE2-bound RBD structure (use the upper-left menu bar to select other antibody data projections):

dms-view renderings for escape maps projected onto antibody-bound RBD structures: