Interactive structural visualizations of escape mutation maps

Below are links to interactive visualizations of the effects of single mutations to the SARS-CoV-2 spike receptor-binding domain (RBD) on recognition by each antibody. These visualizations are built using dms-view. These experiments are described in our preprints here and here, and raw data is available here.

Sites of escape are shown for each antibody, and are mapped to the ACE2-bound RBD structure (PDB 6M0J.

dms-view renderings for escape maps projected onto the ACE2-bound RBD structure (use the upper-left menu bar to select other antibody data projections):

• ACE2-bound RBD

dms-view renderings for escape maps projected onto antibody-bound RBD structures:

• S309-, S304, and S2H14-bound RBD (PDB: 7JX3)

• S309-bound RBD (PDB: 7JX3 with other antibodies removed)