Interactive structural visualizations of escape mutation maps

Below are links to interactive visualizations of the effects of single mutations to the SARS-CoV-2 spike receptor-binding domain (RBD) on recognition by therapeutic antibodies used to treat COVID-19. These visualizations are built using dms-view. These experiments are described in this paper, and raw data is available here.

Sites of escape are shown for each antibody, and are mapped to the ACE2-bound RBD structure (PDB 6M0J or antibody-bound structures (Regeneron antibodies: PDB 6XDG, LY-CoV016: PDB 7C01). For single-antibody bound RBD structures, irrelevant chains were removed from the original pdb file (e.g., REGN10987 chains removed for the REGN10933-specific view)).

dms-view renderings for each antibody’s escape mapped to the ACE2-bound RBD structure:

• ACE2-bound RBD

dms-view renderings for each antibody’s escape mapped to its respective antibody-bound RBD structure:

• REGN10933
• REGN10987
• REGN10933+REGN10987 cocktail
• LY-CoV016