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High-throughput neutralization measurements correlate strongly with evolutionary success of human influenza strains
In a new study posted on bioRxiv today, we used high-throughput sequencing-based neutralization assays to measure ~10,000 titers representing the ability of different human sera to neutralize different H3N2 influenza strains. We then showed that these titers correlate with the actual evolutionary success of these viral strains in the real world, suggesting such experiments could be useful for helping inform vaccine-strain selection.