Fitness effects estimated from observed versus expected counts of mutations.
Analysis described in Bloom and Neher (2023).
Interactive plots for public_2023-10-01 dataset:
Heatmaps of effects of mutations
Expected counts per site
Distribution of estimated mutation fitness effects
Correlations among effect estimates
Correlations of estimates with deep mutational scanning
Effects of fixed mutations
Effects of mutations versus number of descendants
Correlations among estimates from different sequence sets
Comparisons to other methods of estimating mutation effects
See Bloom and Neher (2023) for a paper describing the work.
See https://github.com/jbloomlab/SARS2-mut-fitness for full computer code and data.
See https://jbloomlab.github.io/SARS2-mut-fitness/ for links to all interactive plots.
Here are plots for other datasets: